Critical - Busniess critical Email not delivering/backing up in Production Enviornment Exchange 2010 SP1 RU5 on CAS Servers

Enviornment

All Hyper-V machine

2 DCs Windows 2008 R2 DC,

2 CAS/HT Servers / NLB [Emails backing up -

Errors - 432 4.3.2 STOREDRV.Deliver; recipient thread limit exceeded

or mapidelivery queue connecting or mapidelivery queue active for too long]

2 Mailbox Servers / DAG

2 Edge Servers

All Exchange Server 2010 at SP1 RU5

Emails are delayed / lost.

Please Advice.