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One of HUB/CAS servers can’t connect to mailbox server

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Hi all, hope you can help or at least nudge in the right direction , i have 4 exchange servers 2 HUB/CAS and 2 Mailbox DAG , this issue happened three times one on HUBCAS02 server and two times in HUBCAS01 ,the Issue is suddenly the HUB/CAS server can’t connect to mailbox server ( MBX01) but connect with another server like (MBX02 , another HUB/CAS server , AD servers , …… etc. ) although the MBX01 is up and work good and another HUB/CAS server connect good with same mailbox server (MBX01) , in time the issue happened ihave in event viewer at application this warning :

Log name : Application   Event ID : 1007      Level : Warning   

The Mailbox Replication service was unable to determine the set of active mailbox databases on a mailbox server.

Mailbox server: HV1-MBX01.NMT-EG.LOCAL

Error: MapiExceptionNetworkError: Unable to make admin interface connection to server. (hr=0x80040115, ec=-2147221227)

Diagnostic context:

    ......

    Lid: 15000   dwParam: 0x6BA     Msg: EEInfo: prm[1]: Pointer val: 0x0000000000000000

    Lid: 15000   dwParam: 0x6BA     Msg: EEInfo: prm[2]: Pointer val: 0xCA098C0A00000000

    Lid: 16280   dwParam: 0x6BA     Msg: EEInfo: ComputerName: n/a

    Lid: 8600    dwParam: 0x6BA     Msg: EEInfo: ProcessID: 5980

    Lid: 12696   dwParam: 0x6BA     Msg: EEInfo: Generation Time: 2013-02-04 12:16:54:411

    Lid: 10648   dwParam: 0x6BA     Msg: EEInfo: Generating component: 18

    Lid: 14744   dwParam: 0x6BA     Msg: EEInfo: Status: 10060

    Lid: 9624    dwParam: 0x6BA     Msg: EEInfo: Detection location: 318

    Lid: 13720   dwParam: 0x6BA     Msg: EEInfo: Flags: 0

    Lid: 11672   dwParam: 0x6BA     Msg: EEInfo: NumberOfParameters: 0

    Lid: 24060   StoreEc: 0x80040115

    Lid: 23746 

    Lid: 31938   StoreEc: 0x80040115

    Lid: 19650 

    Lid: 27842   StoreEc: 0x80040115

    Lid: 20866 

    Lid: 29058   StoreEc: 0x80040115

Note : This problem resolved on its own after 20 minutes


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