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error 451 4.4.0 abd 554 No SMTP Service Here when sending from Exchange 2010 mailbox

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We are migrating from Exchange 2003 to 2010.  A month ago I brought the 2010 server online (CAS, Hub Transport and Mailbox on one server).  I configured the send connector to send to our extranal spam filter host using a smart host.  I swear I tested interent bound mail flow and it was working.  THe past month I have been configuring our mobile device management servers to work with Exchange 2010. 

This week I finally migrated my first live mailbox (my personal) and everything appeared to be ok until I sent an internet bound email.   I can send/receive internal emails across servers ok.  I can receive internet email ok.  When I sent something external to no matter what domain I try, the mail gets stuck in the queue with error:

451 4.4.0 Primary target IP address responded with: "554 No SMTP service here (Mode: normal)." Attempted failover to alternate host, but that did not succeed.  Either there are no alternate hosts, or delivery failed to all alternate hosts.

On my send connector, I added the FQDN for my mail server (mail.mydomain.org) (that field had been left blank).  Address space:  SMTP *, 1.  Network:  Route thru smart host and the host info was copy/pasted from my 2003 connector so no spelling mistakes.  I also tried "use the external DNS lookup..." both checked and unchecked.  And source server is listed as my 2010 exchange server.

When I try to telnet to port 25, I get error 550 5.7.1 unable to relay

I have been chasing this issue down for 3 days with no results.  Any input would be appreciated.


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