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Replying to email changes SMTP information

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I have a user when she replies to an outside email, the recipient email address gets changed to the local smtp addressing and it tries to deliver it locally.  Of course, the mailbox is not local so she gets an NDR.  It doesn't matter if the recipient is listed in our GAL or not. She seems to be the only person this is happening to, or that has reported it.  I've tried looking through the event logs but not really sure what to be looking for.

We are Exchange 2010, user is Outlook 2010.  All service packs and updates have been applied to both


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